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The Laboratory for High-Field Imaging and Translational Neuroscience is led by Dr. Fei Du, and is dedicated to conducting MRI/MRS technique developments using a translational neuroscience approach, from bench to bedside. Toward this goal, the lab uses multimodal neuroimaging approaches, brain modulation, and translational animal models to probe abnormalities of brain microstructure, metabolism and function. In particular, a growing body of evidence suggests that a central “immuno-oxidative” pathway involving neuroinflammation, oxidative stress, and neurotransmission dysfunction plays a key role and contributes to distributed brain circuits. With this in mind, we develop novel approaches to directly quantify in vivo glutamate/GABA, glutathione (antioxidant), and redox ratio of NAD+ and NADH, as well as creatine kinase and ATPase activities (mitochondrial function) in the same experimental session. With these novel approaches, we aim to outline the trajectories of biological development in early phases of diseases, such as schizophrenia and Alzheimer’s disease, and to identify a sensitive predictor for the outcomes of disease transition and treatment such as nicotinamide riboside supplement. These works facilitate the translational applications of technical innovations.
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